This revolutionary hydrogen inhalation system is designed to provide a controlled and consistent fraction of inspired hydrogen (FiH₂) by utilizing an inflatable reservoir bag. The system delivers a total gas flow rate of approximately 10 L/min, ensuring that individuals with a minute ventilation at or below this threshold receive a precise FiH₂ within the selected and ideal range (0.5 - 4% H₂).
- Delivers precise hydrogen concentration
- Every inhalation is therapeutic
- Safest hydrogen delivery system on the market
Key Features & Benefits
- Inflatable reservoir bag ensures every breath taken contains intended FiH₂, mitigating variability associated with other direct H₂ flow adjustments
- Adjustable hydrogen flow rate provides precise control over H₂ delivery, accommodating different research parameters and physiological conditions
- Total flow rate of ~10 L/min maintains stable FiH₂ regardless of variations in breathing patterns, tidal volume, or inhalation depth
- Designed to limit safety risks by delivering efficacious amounts of hydrogen without exceeding 4% FiH₂. Levels above this range introduce safety risks, including the potential for hypoxia and flammability concerns.
Therapeutic Considerations and FiH₂ Requirements
The therapeutic effectiveness of hydrogen is dependent on reaching a sufficient concentration of H₂ in cells. Based on leading research, a minimum intracellular H₂ concentration of approximately 5–10 µM is suggested for biological effects to occur. This corresponds to an FiH₂ of at least 1%.
- FiH₂ below 1% may not consistently achieve intracellular concentrations necessary for therapeutic effects.
- Higher FiH₂ concentrations (e.g., 2–4%) can more reliably elevate tissue H₂ levels within the therapeutic range.
- Exceeding 4% FiH₂ introduces safety risks, including the potential for hypoxia and, more critically, flammability concerns.
Understanding FiH₂, Flow Rate Selection, and Flammability Risks
Achieving a target FiH₂ requires consideration of individual respiratory dynamics.
Hydrogen inhalation delivery systems without a controlled total flow rate face significant variability in FiH₂ due to fluctuations in breathing frequency, inhalation volume, and exhalation patterns, and thus less efficacious results.
A direct H₂ flow of 200 mL/min to several liters per minute may be required to achieve an FiH₂ of 4%, depending on individual ventilation rates and most clinical and research environments prohibit hydrogen inhalation devices exceeding 4% FiH₂ due to these safety concerns.
Our inflatable reservoir system ensures stable FiH₂ within a safe and controlled range, optimizing therapeutic potential while adhering to safety and regulatory standards.
Regulatory and Clinical Considerations
Most hospitals, clinics, and research institutions follow strict safety guidelines that prohibit hydrogen inhalation systems exceeding 4% FiH₂. This device is designed to comply with these restrictions while providing reliable and reproducible hydrogen delivery.
Applications
- Preclinical and clinical research on hydrogen therapy
- Investigations into FiH₂-dependent physiological and biochemical responses
- Controlled H₂ exposure studies minimizing confounding variables related to respiratory rate and inhalation depth
This system is designed to address the practical challenges of hydrogen inhalation research while maintaining strict safety and regulatory standards.
